Ezio Bonifacio Selected Research

Autoantigens

1/2022	Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes.
10/2021	100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention.
1/2021	Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial.
1/2021	Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study.
1/2020	Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring.
1/2019	Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level.
1/2018	Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.
1/2018	Novel minor HLA DR associated antigens in type 1 diabetes.
1/2017	CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage.
1/2017	A divergent population of autoantigen-responsive CD4+ T cells in infants prior to β cell autoimmunity.

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Ezio Bonifacio Research Topics

Disease

112	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 01/2002
12	Insulinoma 01/2020 - 10/2004
10	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 05/2008
7	Type 2 Diabetes Mellitus (MODY) 08/2022 - 01/2008
5	Infections 11/2021 - 04/2015
5	Disease Progression 01/2019 - 08/2004
5	Celiac Disease (Celiac Sprue) 01/2019 - 07/2002
4	Hyperglycemia 01/2021 - 01/2007
3	Genetic Risk Score 11/2021 - 01/2019
3	Genetic Predisposition to Disease (Genetic Predisposition) 01/2021 - 04/2005
3	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2019 - 01/2017
3	Neoplasms (Cancer) 01/2019 - 04/2010
3	Birth Weight (Birth Weights) 10/2009 - 01/2004
2	Insulin Resistance 08/2022 - 01/2003
2	Hypersensitivity (Allergy) 11/2021 - 01/2021
2	Obesity 01/2021 - 01/2020
2	Latent Autoimmune Diabetes in Adults 01/2018 - 06/2014
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2018 - 07/2014
2	Asthma (Bronchial Asthma) 01/2017 - 05/2003
1	Necrosis 08/2022
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2021
1	COVID-19 10/2020
1	Diabetes Mellitus 10/2020
1	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 10/2020
1	Cytomegalovirus Infections (Inclusion Disease) 01/2019
1	Opportunistic Infections (Opportunistic Infection) 01/2019
1	Glucose Intolerance 01/2018
1	Chronic Disease (Chronic Diseases) 03/2017
1	Immune System Diseases (Immune Disorders) 01/2017

Drug/Important Bio-Agent (IBA)

74	AutoantibodiesIBA 08/2022 - 01/2002
42	Insulin (Novolin)FDA Link 08/2022 - 02/2004
23	AntigensIBA 01/2020 - 07/2002
21	AutoantigensIBA 01/2022 - 04/2002
14	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2002
12	AntibodiesIBA 12/2021 - 01/2004
9	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 11/2021 - 02/2004
8	EpitopesIBA 01/2019 - 04/2002
7	Zinc Transporter 8IBA 11/2021 - 01/2008
5	ProinsulinIBA 01/2018 - 08/2004
5	Glutens (Glutelin)IBA 06/2011 - 07/2002
4	C-PeptideIBA 08/2022 - 11/2014
4	Tyrosine (L-Tyrosine)FDA Link 11/2021 - 04/2002
4	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2021 - 04/2002
4	TransglutaminasesIBA 11/2021 - 01/2009
4	HLA Antigens (Human Leukocyte Antigens)IBA 10/2020 - 06/2013
4	Biomarkers (Surrogate Marker)IBA 11/2018 - 05/2015
4	Sirolimus (Rapamycin)FDA Link 07/2009 - 06/2006
3	InterferonsIBA 08/2022 - 12/2011
3	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 11/2004
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 05/2003
3	HLA-DRB1*04 antigenIBA 01/2018 - 08/2004
3	CytokinesIBA 01/2018 - 05/2008
3	HLA-DRB1 Chains (HLA DRB1)IBA 01/2018 - 06/2013
3	C-Reactive ProteinIBA 05/2015 - 05/2005
3	Protein Glutamine gamma Glutamyltransferase 2IBA 07/2014 - 02/2011
3	Interleukin-7 (Interleukin 7)IBA 01/2014 - 05/2008
3	Indicators and Reagents (Reagents)IBA 05/2006 - 05/2003
2	LipidsIBA 08/2022 - 11/2011
2	VaccinesIBA 11/2021 - 10/2021
2	Pharmaceutical PreparationsIBA 10/2021 - 01/2017
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021 - 01/2019
2	Blood Glucose (Blood Sugar)IBA 10/2020 - 05/2015
2	Interleukin-7 Receptors (Interleukin 7 Receptor)IBA 01/2020 - 07/2013
2	TetraspaninsIBA 01/2019 - 01/2016
2	Iodide Peroxidase (Deiodinase)IBA 01/2019 - 02/2011
2	Protein Isoforms (Isoforms)IBA 01/2018 - 06/2014
2	Amino Acids FDA Link 01/2018 - 11/2011
2	LuciferasesIBA 01/2018 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 11/2016 - 03/2006
2	Peptides (Polypeptides)IBA 10/2015 - 07/2008
2	Class 8 Receptor-Like Protein Tyrosine PhosphatasesIBA 12/2012 - 06/2011
2	Protein Tyrosine PhosphatasesIBA 07/2008 - 02/2004
1	Adenosine Triphosphatases (ATPase)IBA 01/2022
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 11/2021
1	ImmunosorbentsIBA 10/2020
1	AngiotensinsIBA 10/2020
1	EnzymesIBA 10/2020
1	Interleukin-17 (Interleukin 17)IBA 01/2018
1	zinc-binding protein (zinc binding protein)IBA 01/2018
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2018
1	HLA-DQB1 antigen (HLA DQB1)IBA 01/2018
1	interleukin-21 (interleukin 21)IBA 01/2018
1	Interleukin-22 (IL-22)IBA 01/2018
1	Messenger RNA (mRNA)IBA 09/2017
1	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 01/2017
1	HLA-A*02:01 antigenIBA 01/2017
1	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 01/2017
1	Nerve Growth Factors (Neurotrophins)IBA 01/2017
1	OvalbuminIBA 01/2017
1	Nerve Growth Factor (NGF)IBA 01/2017
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017

Therapy/Procedure

7	Therapeutics 10/2021 - 04/2008
7	Transplantation 01/2019 - 05/2008
6	Islets of Langerhans Transplantation 03/2014 - 01/2006
4	Immunotherapy 10/2021 - 09/2012
3	Mucosal Administration 04/2008 - 10/2004
3	Gluten-Free Diet 01/2005 - 07/2002
1	Stem Cell Transplantation 01/2019
1	Lasers (Laser) 01/2018
1	Heterologous Transplantation (Xenotransplantation) 01/2017